Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice

Splicing factor mutations are characteristic of myelodysplastic syndromes (MDS) and related myeloid neoplasms and implicated in their pathogenesis, but their roles in the development of MDS have not been fully elucidated. In the present study, we investigated the consequence of mutant Srsf2 expressi...

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Vydáno v:Blood
Hlavní autoři: Kon, Ayana, Yamazaki, Satoshi, Nannya, Yasuhito, Kataoka, Keisuke, Ota, Yasunori, Nakagawa, Masahiro Marshall, Yoshida, Kenichi, Shiozawa, Yusuke, Morita, Maiko, Yoshizato, Tetsuichi, Sanada, Masashi, Nakayama, Manabu, Koseki, Haruhiko, Nakauchi, Hiromitsu, Ogawa, Seishi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888285/
https://ncbi.nlm.nih.gov/pubmed/29146882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-01-762393
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