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Terminal Alkynes as Raman Probes of α-Synuclein in Solution and in Cells

Conformational changes of α-synuclein (α-syn) are central to its biological function and Parkinson’s disease pathology. Here, terminal alkynes (homopropargylglycine) were employed as environmentally sensitive Raman probes at residues 1, 5, 116, and 127, to characterize soluble (disordered), micelle-...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chembiochem
Main Authors: Flynn, Jessica D., Gimmen, Megan Y., Dean, Dexter N., Lacy, Shannon M., Lee, Jennifer C.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269816/
https://ncbi.nlm.nih.gov/pubmed/31960993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000026
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