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Segmental (13)C-labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation
Mapping conformational changes of α-synuclein (α-syn) from soluble, unstructured monomers to β-sheet-rich aggregates is crucial towards understanding amyloid formation. Here, we use Raman microspectroscopy to spatially resolve conformational heterogeneity of amyloid aggregates and monitor amyloid fo...
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| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6688611/ https://ncbi.nlm.nih.gov/pubmed/30371967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201809865 |
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