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Segmental (13)C-labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation

Mapping conformational changes of α-synuclein (α-syn) from soluble, unstructured monomers to β-sheet-rich aggregates is crucial towards understanding amyloid formation. Here, we use Raman microspectroscopy to spatially resolve conformational heterogeneity of amyloid aggregates and monitor amyloid fo...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Flynn, Jessica D., Jiang, Zhiping, Lee, Jennifer C.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688611/
https://ncbi.nlm.nih.gov/pubmed/30371967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201809865
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