Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling pathways controlling APP transport to the synapse in axons and dendrites remain to be identified. Having previously shown that Huntingtin (HT...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bruyère, Julie, Abada, Yah-Se, Vitet, Hélène, Fontaine, Gaëlle, Deloulme, Jean-Christophe, Cès, Aurélia, Denarier, Eric, Pernet-Gallay, Karin, Andrieux, Annie, Humbert, Sandrine, Potier, Marie-Claude, Delatour, Benoît, Saudou, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269668/
https://ncbi.nlm.nih.gov/pubmed/32452382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56371
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