Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived neurotrophic factor (BDNF) levels, but non‐specific overexpression of B...

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Библиографические подробности
Опубликовано в: :EMBO Mol Med
Главные авторы: Ehinger, Yann, Bruyère, Julie, Panayotis, Nicolas, Abada, Yah‐Se, Borloz, Emilie, Matagne, Valérie, Scaramuzzino, Chiara, Vitet, Hélène, Delatour, Benoit, Saidi, Lydia, Villard, Laurent, Saudou, Frédéric, Roux, Jean‐Christophe
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
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Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005633/
https://ncbi.nlm.nih.gov/pubmed/31913581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910889
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