Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived neurotrophic factor (BDNF) levels, but non‐specific overexpression of B...

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Pubblicato in:EMBO Mol Med
Autori principali: Ehinger, Yann, Bruyère, Julie, Panayotis, Nicolas, Abada, Yah‐Se, Borloz, Emilie, Matagne, Valérie, Scaramuzzino, Chiara, Vitet, Hélène, Delatour, Benoit, Saidi, Lydia, Villard, Laurent, Saudou, Frédéric, Roux, Jean‐Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005633/
https://ncbi.nlm.nih.gov/pubmed/31913581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910889
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