Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice

Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived neurotrophic factor (BDNF) levels, but non‐specific overexpression of B...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Mol Med
Prif Awduron: Ehinger, Yann, Bruyère, Julie, Panayotis, Nicolas, Abada, Yah‐Se, Borloz, Emilie, Matagne, Valérie, Scaramuzzino, Chiara, Vitet, Hélène, Delatour, Benoit, Saidi, Lydia, Villard, Laurent, Saudou, Frédéric, Roux, Jean‐Christophe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005633/
https://ncbi.nlm.nih.gov/pubmed/31913581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910889
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