Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases

Most of the current antibody-drug conjugates (ADCs) in clinic are heterogeneous mixtures. To produce homogeneous ADCs, established procedures often require multiple steps or long reaction times. The introduced mutations or foreign sequences may cause high immunogenicity. Here, we explore a new conce...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Dai, Zhefu, Zhang, Xiao-Nan, Nasertorabi, Fariborz, Cheng, Qinqin, Li, Jiawei, Katz, Benjamin B., Smbatyan, Goar, Pei, Hua, Louie, Stan G., Lenz, Heinz-Josef, Stevens, Raymond C., Zhang, Yong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2020
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269645/
https://ncbi.nlm.nih.gov/pubmed/32537509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6752
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