Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases

Most of the current antibody-drug conjugates (ADCs) in clinic are heterogeneous mixtures. To produce homogeneous ADCs, established procedures often require multiple steps or long reaction times. The introduced mutations or foreign sequences may cause high immunogenicity. Here, we explore a new conce...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Dai, Zhefu, Zhang, Xiao-Nan, Nasertorabi, Fariborz, Cheng, Qinqin, Li, Jiawei, Katz, Benjamin B., Smbatyan, Goar, Pei, Hua, Louie, Stan G., Lenz, Heinz-Josef, Stevens, Raymond C., Zhang, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269645/
https://ncbi.nlm.nih.gov/pubmed/32537509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6752
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