A ribose-functionalized NAD(+) with unexpected high activity and selectivity for protein poly-ADP-ribosylation

Nicotinamide adenine dinucleotide (NAD(+))-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP-ribosylation (PARylation). Here we explore che...

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Publicado no:Nat Commun
Main Authors: Zhang, Xiao-Nan, Cheng, Qinqin, Chen, Jingwen, Lam, Albert T., Lu, Yanran, Dai, Zhefu, Pei, Hua, Evdokimov, Nikolai M., Louie, Stan G., Zhang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744458/
https://ncbi.nlm.nih.gov/pubmed/31519936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12215-4
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