Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination

Protein poly(ADP-ribosyl)ation and ubiquitination are two key post-translational modifications regulating many biological processes. Through crystallographic and biochemical analysis, we show that the RNF146 WWE domain recognizes poly(ADP-ribose) (PAR) by interacting with iso-ADP-ribose (iso-ADPR),...

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Bibliografiske detaljer
Main Authors: Wang, Zhizhi, Michaud, Gregory A., Cheng, Zhihong, Zhang, Yue, Hinds, Thomas R., Fan, Erkang, Cong, Feng, Xu, Wenqing
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278890/
https://ncbi.nlm.nih.gov/pubmed/22267412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.182618.111
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