Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases

Most of the current antibody-drug conjugates (ADCs) in clinic are heterogeneous mixtures. To produce homogeneous ADCs, established procedures often require multiple steps or long reaction times. The introduced mutations or foreign sequences may cause high immunogenicity. Here, we explore a new conce...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Dai, Zhefu, Zhang, Xiao-Nan, Nasertorabi, Fariborz, Cheng, Qinqin, Li, Jiawei, Katz, Benjamin B., Smbatyan, Goar, Pei, Hua, Louie, Stan G., Lenz, Heinz-Josef, Stevens, Raymond C., Zhang, Yong
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269645/
https://ncbi.nlm.nih.gov/pubmed/32537509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6752
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