Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K(ATP) channel overactivity

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) K(ATP) channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abn...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa M., Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Concise Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269588/
https://ncbi.nlm.nih.gov/pubmed/31821173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130571
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