Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K(ATP) channel overactivity

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) K(ATP) channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abn...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa M., Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2020
Aiheet:
Concise Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269588/
https://ncbi.nlm.nih.gov/pubmed/31821173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130571
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