Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K(ATP) channel overactivity

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) K(ATP) channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abn...

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Vydáno v:J Clin Invest
Hlavní autoři: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa M., Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269588/
https://ncbi.nlm.nih.gov/pubmed/31821173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130571
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