Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K(ATP) channel overactivity

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) K(ATP) channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abn...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: McClenaghan, Conor, Huang, Yan, Yan, Zihan, Harter, Theresa M., Halabi, Carmen M., Chalk, Rod, Kovacs, Attila, van Haaften, Gijs, Remedi, Maria S., Nichols, Colin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269588/
https://ncbi.nlm.nih.gov/pubmed/31821173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130571
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