Chronic mTOR activation induces a degradative smooth muscle cell phenotype

Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which...

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Pubblicato in:J Clin Invest
Autori principali: Li, Guangxin, Wang, Mo, Caulk, Alexander W., Cilfone, Nicholas A., Gujja, Sharvari, Qin, Lingfeng, Chen, Pei-Yu, Chen, Zehua, Yousef, Sameh, Jiao, Yang, He, Changshun, Jiang, Bo, Korneva, Arina, Bersi, Matthew R., Wang, Guilin, Liu, Xinran, Mehta, Sameet, Geirsson, Arnar, Gulcher, Jeffrey R., Chittenden, Thomas W., Simons, Michael, Humphrey, Jay D., Tellides, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269581/
https://ncbi.nlm.nih.gov/pubmed/32039915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131048
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