Chronic mTOR activation induces a degradative smooth muscle cell phenotype

Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Li, Guangxin, Wang, Mo, Caulk, Alexander W., Cilfone, Nicholas A., Gujja, Sharvari, Qin, Lingfeng, Chen, Pei-Yu, Chen, Zehua, Yousef, Sameh, Jiao, Yang, He, Changshun, Jiang, Bo, Korneva, Arina, Bersi, Matthew R., Wang, Guilin, Liu, Xinran, Mehta, Sameet, Geirsson, Arnar, Gulcher, Jeffrey R., Chittenden, Thomas W., Simons, Michael, Humphrey, Jay D., Tellides, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269581/
https://ncbi.nlm.nih.gov/pubmed/32039915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131048
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