ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo

Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent intro...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Samuelsen, Ørjan, Åstrand, Ove Alexander Høgmoen, Fröhlich, Christopher, Heikal, Adam, Skagseth, Susann, Carlsen, Trine Josefine Olsen, Leiros, Hanna-Kirsti S., Bayer, Annette, Schnaars, Christian, Kildahl-Andersen, Geir, Lauksund, Silje, Finke, Sarah, Huber, Sandra, Gjøen, Tor, Andresen, Adriana Magalhaes Santos, Økstad, Ole Andreas, Rongved, Pål
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269481/
https://ncbi.nlm.nih.gov/pubmed/32179522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02415-19
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