Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2–Mediated Blood Pressure Reduction Independent of Cystogenesis

BACKGROUND: Hypertension often occurs before renal function deteriorates in autosomal dominant polycystic kidney disease (ADPKD). It is unknown whether the Pkd1 gene product polycystin-1—the predominant causal factor in ADPKD—itself contributes to ADPKD hypertension independent of cystogenesis. METH...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Lakshmipathi, Jayalakshmi, Gao, Yang, Hu, Chunyan, Stuart, Deborah, Genzen, Jonathan, Ramkumar, Nirupama, Kohan, Donald E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2020
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269346/
https://ncbi.nlm.nih.gov/pubmed/32300065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019090934
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