Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule

BACKGROUND: The potassium channel Kir4.1 forms the Kir4.1/Kir5.1 heterotetramer in the basolateral membrane of the distal convoluted tubule (DCT) and plays an important role in the regulation of the thiazide-sensitive NaCl cotransporter (NCC). Kidney-specific deletion of the ubiquitin ligase Nedd4-2...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Wu, Peng, Su, Xiao-Tong, Gao, Zhong-Xiuzi, Zhang, Dan-Dan, Duan, Xin-Peng, Xiao, Yu, Staub, Olivier, Wang, Wen-Hui, Lin, Dao-Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2020
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269345/
https://ncbi.nlm.nih.gov/pubmed/32295826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019090923
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