Deletion of Kir5.1 abolishes the effect of high Na(+) intake on Kir4.1 and Na(+)-Cl(−) cotransporter

High sodium (HS) intake inhibited epithelial Na(+) channel (ENaC) in the aldosterone-sensitive distal nephron and Na(+)-Cl(−) cotransporter (NCC) by suppressing basolateral Kir4.1/Kir5.1 in the distal convoluted tubule (DCT), thereby increasing renal Na(+) excretion but not affecting K(+) excretion....

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Duan, Xin-Peng, Wu, Peng, Zhang, Dan-Dan, Gao, Zhong-Xiuzi, Xiao, Yu, Ray, Evan C., Wang, Wen-Hui, Lin, Dao-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285650/
https://ncbi.nlm.nih.gov/pubmed/33900854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00004.2021
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