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Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule

Cytochrome P-450 (Cyp) epoxygenase-dependent metabolites of arachidonic acid (AA) have been shown to inhibit renal Na(+) transport, and inhibition of Cyp-epoxygenase is associated with salt-sensitive hypertension. We used the patch-clamp technique to examine whether Cyp-epoxygenase-dependent AA meta...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Wang, Ming-Xiao, Wang, Li-Jun, Xiao, Yu, Zhang, Dan-Dan, Duan, Xin-Peng, Wang, Wen-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311705/
https://ncbi.nlm.nih.gov/pubmed/32308018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00018.2020
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