Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron

Kir4.1/5.1 heterotetramer participates in generating the negative cell membrane potential in distal convoluted tubule (DCT) and plays a critical role in determining the activity of Na-Cl cotransporter (NCC). Kir5.1 contains a phosphothreonine motif at its COOH terminus (AA249–252). Coimmunoprecipita...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Wang, Ming-Xiao, Su, Xiao-Tong, Wu, Peng, Gao, Zhong-Xiuzi, Wang, Wen-Hui, Staub, Olivier, Lin, Dao-Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230743/
https://ncbi.nlm.nih.gov/pubmed/29897283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00059.2018
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