Tbx5 inhibits hedgehog signaling in determination of digit identity

Dominant TBX5 mutation causes Holt-Oram syndrome (HOS), which is characterized by limb defects in humans, but the underlying mechanistic basis is unclear. We used a mouse model with Tbx5 conditional knockdown in Hh-receiving cells (marked by Gli1+) during E8 to E10.5, a previously established model...

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Udgivet i:Hum Mol Genet
Main Authors: Xu, Huiting, Xiang, Menglan, Qin, Yushu, Cheng, Henghui, Chen, Duohua, Fu, Qiang, Zhang, Ke K, Xie, Linglin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7268785/
https://ncbi.nlm.nih.gov/pubmed/31373354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz185
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