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Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function
Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is epigenetically silenced. Here, we demonstrate that human...
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| Publicado no: | mBio |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7267885/ https://ncbi.nlm.nih.gov/pubmed/32487757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01038-20 |
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