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A mammalian herpesvirus uses non-canonical expression and processing mechanisms to generate viral microRNAs
Canonical primary microRNA (pri-miRNA) precursors are transcribed by RNA polymerase II and then processed by the Drosha endonuclease to generate ∼60 nt pre-miRNA hairpins. pre-miRNAs in turn are cleaved by Dicer to generate mature miRNAs. Previously, some short introns, called miRtrons, were reporte...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818755/ https://ncbi.nlm.nih.gov/pubmed/20129062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.016 |
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