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STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers
The cohesin subunit STAG2 has emerged as a recurrently inactivated tumor suppressor in human cancers. Using candidate approaches, recent studies have revealed a synthetic lethal interaction between STAG2 and its paralog STAG1. To systematically probe genetic vulnerabilities in the absence of STAG2,...
שמור ב:
| הוצא לאור ב: | Life Sci Alliance |
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| Main Authors: | , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Life Science Alliance LLC
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7266993/ https://ncbi.nlm.nih.gov/pubmed/32467316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000725 |
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