STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers

The cohesin subunit STAG2 has emerged as a recurrently inactivated tumor suppressor in human cancers. Using candidate approaches, recent studies have revealed a synthetic lethal interaction between STAG2 and its paralog STAG1. To systematically probe genetic vulnerabilities in the absence of STAG2,...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Life Sci Alliance
Main Authors: van der Lelij, Petra, Newman, Joseph A, Lieb, Simone, Jude, Julian, Katis, Vittorio, Hoffmann, Thomas, Hinterndorfer, Matthias, Bader, Gerd, Kraut, Norbert, Pearson, Mark A, Peters, Jan-Michael, Zuber, Johannes, Gileadi, Opher, Petronczki, Mark
Format: Artigo
Jezik:Inglês
Izdano: Life Science Alliance LLC 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266993/
https://ncbi.nlm.nih.gov/pubmed/32467316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000725
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki