CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition

The deletion of 11q (del(11q)) invariably comprises ATM gene in chronic lymphocytic leukemia (CLL). Concomitant mutations in this gene in the remaining allele have been identified in 1/3 of CLL cases harboring del(11q), being the biallelic loss of ATM associated with adverse prognosis. Although the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Quijada-Álamo, Miguel, Hernández-Sánchez, María, Alonso-Pérez, Verónica, Rodríguez-Vicente, Ana E., García-Tuñón, Ignacio, Martín-Izquierdo, Marta, Hernández-Sánchez, Jesús María, Herrero, Ana B., Bastida, José María, San Segundo, Laura, Gruber, Michaela, García, Juan Luis, Yin, Shanye, ten Hacken, Elisa, Benito, Rocío, Ordóñez, José Luis, Wu, Catherine J., Hernández-Rivas, Jesús María
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266745/
https://ncbi.nlm.nih.gov/pubmed/31974435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0714-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados