Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome

Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a derivative of the prototype macrolide erythromycin with...

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Udgivet i:RNA
Main Authors: Pichkur, Evgeny B., Paleskava, Alena, Tereshchenkov, Andrey G., Kasatsky, Pavel, Komarova, Ekaterina S., Shiriaev, Dmitrii I., Bogdanov, Alexey A., Dontsova, Olga A., Osterman, Ilya A., Sergiev, Petr V., Polikanov, Yury S., Myasnikov, Alexander G., Konevega, Andrey L.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266154/
https://ncbi.nlm.nih.gov/pubmed/32144191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073817.119
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