Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

Translation of modulation of drug target activity to therapeutic effect is a critical aspect for all drug discovery programs. In this work we describe the profiling of a non-receptor tyrosine-protein kinase (TYK2) inhibitor which shows a functionally relevant potency shift between human and preclini...

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Publicat a:Sci Rep
Autors principals: Gerstenberger, Brian S., Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Fensome, Andrew, Gifford, Roger, Griffor, Matthew C., Hegen, Martin, Hollingshead, Brett D., Knafels, John D., Lin, Tsung H., Smith, James F., Vajdos, Felix F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265552/
https://ncbi.nlm.nih.gov/pubmed/32488071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65762-y
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