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AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2
MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression in mammals. miRNA 3’ ends are subject to frequent sequence modifications, which have been proposed to affect miRNA stability. However, the underlying mechanism is not well understood. Here, by genetic and biochemic...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7265490/ https://ncbi.nlm.nih.gov/pubmed/32488030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16533-w |
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