Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the maturation of three pri-miR-9 paralogs, which encode...

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Publicado en:Cell Rep
Main Authors: Bofill-De Ros, Xavier, Kasprzak, Wojciech K., Bhandari, Yuba, Fan, Lixin, Cavanaugh, Quinn, Jiang, Minjie, Dai, Lisheng, Yang, Acong, Shao, Tie-Juan, Shapiro, Bruce A., Wang, Yun-Xing, Gu, Shuo
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369706/
https://ncbi.nlm.nih.gov/pubmed/30625327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.054
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