Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity. To understand how pri-miRNA sequence and structure influence Drosha cleavage, we studied the maturation of three pri-miR-9 paralogs, which encode...

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Vydáno v:Cell Rep
Hlavní autoři: Bofill-De Ros, Xavier, Kasprzak, Wojciech K., Bhandari, Yuba, Fan, Lixin, Cavanaugh, Quinn, Jiang, Minjie, Dai, Lisheng, Yang, Acong, Shao, Tie-Juan, Shapiro, Bruce A., Wang, Yun-Xing, Gu, Shuo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369706/
https://ncbi.nlm.nih.gov/pubmed/30625327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.054
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