CD8(+) T cells in lymphoid tissues exhibit distinct functional and transcriptional signatures that associate with elite control of HIV

Elite control of HIV replication is associated with polyfunctional lymphoid memory CD8(+) T cells that lack overt cytolytic activity and home to B cell follicles. The functional properties of circulating CD8(+) T cells have been associated with immune control of HIV. However, viral replication occur...

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Udgivet i:Sci Transl Med
Main Authors: Nguyen, Son, Deleage, Claire, Darko, Samuel, Ransier, Amy, Truong, Duc, Agarwal, Divyansh, Japp, Alberto Sada, Wu, Vincent H., Kuri-Cervantes, Leticia, Abdel-Mohsen, Mohamed, Del Rio Estrada, Perla M., Ablanedo-Terrazas, Yuria, Gostick, Emma, Hoxie, James A., Zhang, Nancy R., Naji, Ali, Reyes-Terán, Gustavo, Estes, Jacob D., Price, David A., Douek, Daniel C., Deeks, Steven G., Buggert, Marcus, Betts, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265335/
https://ncbi.nlm.nih.gov/pubmed/31852798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax4077
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