Colistin for the treatment of urinary tract infections caused by extremely drug-resistant Pseudomonas aeruginosa: a call for a dose update

OBJECTIVES: Optimal dosage regimens of colistin for the treatment of urinary tract infections (UTI) are unknown. Colistimethate sodium (CMS), the inactive prodrug of colistin, is mainly excreted in urine and converts to colistin after filtration by glomeruli, suggesting that concentrations of colist...

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Udgivet i:J Infect
Main Authors: Sorlí, Luisa, Luque, Sonia, Li, Jian, Campillo, Núria, Danés, Marc, Montero, Milagro, Segura, Concha, Grau, Santiago, Horcajada, Juan Pablo
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265153/
https://ncbi.nlm.nih.gov/pubmed/31265867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinf.2019.06.011
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