Efficacy of Ceftolozane-Tazobactam in Combination with Colistin against Extensively Drug-Resistant Pseudomonas aeruginosa, Including High-Risk Clones, in an In Vitro Pharmacodynamic Model

Combination therapy is an attractive therapeutic option for extensively drug-resistant (XDR) Pseudomonas aeruginosa infections. Colistin has been the only treatment available for these infections for many years, but its results are suboptimal. Ceftolozane-tazobactam (C/T) is a newly available therap...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Montero, María, Domene Ochoa, Sandra, López-Causapé, Carla, VanScoy, Brian, Luque, Sonia, Sorlí, Luisa, Campillo, Núria, Angulo-Brunet, Ariadna, Padilla, Eduardo, Prim, Núria, Pomar, Virginia, Rivera, Alba, Grau, Santiago, Ambrose, Paul G., Oliver, Antonio, Horcajada, Juan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179322/
https://ncbi.nlm.nih.gov/pubmed/32041712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02542-19
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