Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2

Oligoadenylate synthetases (OASs) are a family of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor. Upon binding dsRNA, OAS undergoes a conformational change and is activated to polymerize ATP into 2′-5′-oligoadenylate chains. The OAS family consists of several iso...

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Veröffentlicht in:Biophys J
Hauptverfasser: Koul, Amit, Gemmill, Darren, Lubna, Nikhat, Meier, Markus, Krahn, Natalie, Booy, Evan P., Stetefeld, Jörg, Patel, Trushar R., McKenna, Sean A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264852/
https://ncbi.nlm.nih.gov/pubmed/32413313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.04.025
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