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Electroosmosis Dominates Electrophoresis of Antibiotic Transport Across the Outer Membrane Porin F

We report that the dynamics of antibiotic capture and transport across a voltage-biased OmpF nanopore is dominated by the electroosmotic flow rather than the electrophoretic force. By reconstituting an OmpF porin in an artificial lipid bilayer and applying an electric field across it, we are able to...

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Bibliographic Details
Published in:Biophys J
Main Authors: Bafna, Jayesh A., Pangeni, Sushil, Winterhalter, Mathias, Aksoyoglu, M. Alphan
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264812/
https://ncbi.nlm.nih.gov/pubmed/32348725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.04.011
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