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Ampicillin permeation across OmpF, the major outer-membrane channel in Escherichia coli
The outer cell wall of the Gram-negative bacteria is a crucial barrier for antibiotics to reach their target. Here, we show that the chemical stability of the widely used antibiotic ampicillin is a major factor in the permeation across OmpF to reach the target in the periplasm. Using planar lipid bi...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5936826/ https://ncbi.nlm.nih.gov/pubmed/29540483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000705 |
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