Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells

Protein kinase CK2 downregulation induces premature senescence in various human cell types via activation of the reactive oxygen species (ROS)–p53–p21(Cip1/WAF1) pathway. The transcription factor “nuclear factor erythroid 2-related factor 2” (Nrf2) plays an important role in maintaining intracellula...

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Detalhes bibliográficos
Publicado no:BMB Rep
Main Authors: Jang, Da Eun, Song, Junbin, Park, Jeong-Woo, Yoon, Soo-Hyun, Bae, Young-Seuk
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262510/
https://ncbi.nlm.nih.gov/pubmed/32317087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2020.53.5.044
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