SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity

Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The KEAP1 (kelch like ECH associated protein 1)-NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) pathway is a pivotal defense mechanism ag...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Lee, Da Hyun, Park, Jeong Su, Lee, Yu Seol, Han, Jisu, Lee, Dong-Kyu, Kwon, Sung Won, Han, Dai Hoon, Lee, Yong-Ho, Bae, Soo Han
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595589/
https://ncbi.nlm.nih.gov/pubmed/31913745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1712108
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