SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity

Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The KEAP1 (kelch like ECH associated protein 1)-NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) pathway is a pivotal defense mechanism ag...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Autophagy
Prif Awduron: Lee, Da Hyun, Park, Jeong Su, Lee, Yu Seol, Han, Jisu, Lee, Dong-Kyu, Kwon, Sung Won, Han, Dai Hoon, Lee, Yong-Ho, Bae, Soo Han
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595589/
https://ncbi.nlm.nih.gov/pubmed/31913745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1712108
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg