Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Disruption of proteostasis, or protein homeostasis, is often associated with aberrant accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to cells by removing toxic protein aggregates and injured organelles in response to proteotoxic stress. However, the exact mecha...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Lim, Junghyun, Lachenmayer, M. Lenard, Wu, Shuai, Liu, Wenchao, Kundu, Mondira, Wang, Rong, Komatsu, Masaaki, Oh, Young J., Zhao, Yanxiang, Yue, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344198/
https://ncbi.nlm.nih.gov/pubmed/25723488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004987
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