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Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer

Autophagy and the Keap1–Nrf2 system are major cellular defense mechanisms against metabolic and oxidative stress. These two systems are linked via phosphorylation of the ubiquitin binding autophagy receptor protein p62/SQSTM1 in the p62–Keap1–Nrf2 pathway. The p62–Keap1–Nrf2 pathway plays a protecti...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Ichimura, Yoshinobu, Komatsu, Masaaki
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999793/
https://ncbi.nlm.nih.gov/pubmed/29930914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00210
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