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Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
Nrf2 (nuclear factor [erythroid-derived 2]-like 2; the transcriptional master regulator of the antioxidant stress response) is regulated through interaction with its cytoplasmic inhibitor Keap1 (Kelch-like ECH-associated protein 1), which under basal conditions targets Nrf2 for proteasomal degrad...
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| Publié dans: | Acta Neuropathol Commun |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5088660/ https://ncbi.nlm.nih.gov/pubmed/27799074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0384-6 |
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