Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis

Activation of the Nrf2-Keap1 pathway, the main intracellular defense against environmental stress, has been observed in several human cancers, including hepatocellular carcinoma (HCC). Here, we assessed whether distinct mechanisms of activation may be involved at different stages of hepatocarcinogen...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Orrù, Claudia, Perra, Andrea, Kowalik, Marta Anna, Rizzolio, Sabrina, Puliga, Elisabetta, Cabras, Lavinia, Giordano, Silvia, Columbano, Amedeo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463589/
https://ncbi.nlm.nih.gov/pubmed/32824383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082305
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