ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer

Lineage plasticity is a prominent feature of pancreatic ductal adenocarcinoma (PDA) cells, which can occur via deregulation of lineage-specifying transcription factors. Here, we show that the zinc finger protein ZBED2 is aberrantly expressed in PDA and alters tumor cell identity in this disease. Une...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Somerville, Tim D. D., Xu, Yali, Wu, Xiaoli S., Maia-Silva, Diogo, Hur, Stella K., de Almeida, Larissa M. N., Preall, Jonathan B., Koo, Peter K., Vakoc, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261015/
https://ncbi.nlm.nih.gov/pubmed/32385160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921484117
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