Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse pancreatic cancer cells can influence the phenotype of non-neoplastic ce...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Somerville, Tim DD, Biffi, Giulia, Daßler-Plenker, Juliane, Hur, Stella K, He, Xue-Yan, Vance, Krysten E, Miyabayashi, Koji, Xu, Yali, Maia-Silva, Diogo, Klingbeil, Olaf, Demerdash, Osama E, Preall, Jonathan B, Hollingsworth, Michael A, Egeblad, Mikala, Tuveson, David A, Vakoc, Christopher R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200154/
https://ncbi.nlm.nih.gov/pubmed/32329713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53381
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