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Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3

Rabies virus (RV) of the Rhabdoviridae family grows in alpha/beta interferon (IFN)-competent cells, suggesting the existence of viral mechanisms preventing IFN gene expression. We here identify the viral phosphoprotein P as the responsible IFN antagonist. The critical involvement of P was first sugg...

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Autors principals: Brzózka, Krzysztof, Finke, Stefan, Conzelmann, Karl-Klaus
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143667/
https://ncbi.nlm.nih.gov/pubmed/15919920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7673-7681.2005
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