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Massively parallel CRISPRi assays reveal concealed thermodynamic determinants of dCas12a binding
The versatility of CRISPR-Cas endonucleases as a tool for biomedical research has led to diverse applications in gene editing, programmable transcriptional control, and nucleic acid detection. Most CRISPR-Cas systems, however, suffer from off-target effects and unpredictable nonspecific binding that...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7260945/ https://ncbi.nlm.nih.gov/pubmed/32376630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918685117 |
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