Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study

It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D migh...

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Detalhes bibliográficos
Publicado no:Pharmacogenomics J
Main Authors: Smit, Roelof AJ, Trompet, Stella, Leong, Aaron, Goodarzi, Mark O, Postmus, Iris, Warren, Helen, Theusch, Elizabeth, Barnes, Michael R, Arsenault, Benoit J, Li, Xiaohui, Feng, QiPing, Chasman, Daniel I, Cupples, L Adrienne, Hitman, Graham A, Krauss, Ronald M, Psaty, Bruce M, Rotter, Jerome I, le Cessie, Saskia, Stein, C Michael, Jukema, J Wouter
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260089/
https://ncbi.nlm.nih.gov/pubmed/31801993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-019-0125-x
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