Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual normal hematopoietic stem and progenitor cells (HSPCs) are impeded in AML-infiltrated bone marrow (BM). The underlyin...

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Vydáno v:J Clin Invest
Hlavní autoři: Waclawiczek, Alexander, Hamilton, Ashley, Rouault-Pierre, Kevin, Abarrategi, Ander, Albornoz, Manuel Garcia, Miraki-Moud, Farideh, Bah, Nourdine, Gribben, John, Fitzgibbon, Jude, Taussig, David, Bonnet, Dominique
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260026/
https://ncbi.nlm.nih.gov/pubmed/32364536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133187
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