Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual normal hematopoietic stem and progenitor cells (HSPCs) are impeded in AML-infiltrated bone marrow (BM). The underlyin...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Waclawiczek, Alexander, Hamilton, Ashley, Rouault-Pierre, Kevin, Abarrategi, Ander, Albornoz, Manuel Garcia, Miraki-Moud, Farideh, Bah, Nourdine, Gribben, John, Fitzgibbon, Jude, Taussig, David, Bonnet, Dominique
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260026/
https://ncbi.nlm.nih.gov/pubmed/32364536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133187
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