Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

Chimeric antigen receptor–T (CAR-T) cell therapies can eliminate relapsed and refractory tumors, but the durability of antitumor activity requires in vivo persistence. Differential signaling through the CAR costimulatory domain can alter the T cell metabolism, memory differentiation, and influence l...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Guedan, Sonia, Madar, Aviv, Casado-Medrano, Victoria, Shaw, Carolyn, Wing, Anna, Liu, Fang, Young, Regina M., June, Carl H., Posey, Avery D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260017/
https://ncbi.nlm.nih.gov/pubmed/32069268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI133215
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